Neurocysticercosis and HIV Infection: what can we learn from the published literature? / Neurocisticercosis e infección por VIH: ¿Qué se puede aprender de la literatura reportada?

ABSTRACT Infections caused by the human immunodeficiency virus (HIV) and by the larvae of Taenia solium (i.e., cysticercosis) are still widespread in many developing countries. Both pathologies modify host immune status and it is possible that HIV infection may modulate the frequency and pathogeny of cysticercosis of the central nervous system (i.e., neurocysticercosis [NCC]). Objective: To describe published cases of NCC among HIV-positive patients and to evaluate whether the characteristics of NCC, including frequency, symptoms, radiological appearance, and response to treatment differed between HIV-positive and HIV-negative patients. Methods: Forty cases of NCC/HIV co-infected patients were identified in the literature. Clinical and radiological characteristics, as well as response to treatment, were compared with non-matching historical series of NCC patients without HIV infection. Results: Most of these patients had seizures and multiple vesicular parasites located in parenchyma. Clinical and radiological characteristics were similar between HIV-positive and HIV-negative patients with NCC, as well as between immunocompromised and non-immunocompromised HIV-positive patients. Conclusion: Our review did not reveal clear interactions between HIV and NCC. This may be partially due to the small number of cases and reliance on published research. A systematic, multi-institutional effort aiming to report all the cases of this dual pathology is needed to confirm this finding and to clarify the possible relationship between both pathogens.

RESUMO Las infecciones causadas por el virus de inmunodeficiencia humana (VIH) y la larva de la Tenia solium siguen estando diseminadas en países en vías de desarrollo. Ambas patologías modifican el estado inmune y es posible que la infección por el VIH module la frecuencia y la patología de la neurocisticercosis (NCC). Objetivo: Describir los casos publicados de NCC en los pacientes VIH positivos y evaluar si las características de la NCC, incluyendo frecuencia, síntomas, presentación radiológica, respuesta a tratamiento, difieren entre los sujetos VIH positivos y VIH negativos. Métodos: Cuarenta casos con coinfección NCC/VIH fueron identificados en la literatura. Se compararon sus características clínico-radiológicas, así como su respuesta al tratamiento con diferentes series de casos históricos no pareados. Resultados: La mayoría de los pacientes NCC/VIH tenían epilepsia y múltiples parásitos vesiculares en el parénquima. Las características clínico-radiológicas de la NCC así como la evolución de los pacientes fueron similares entre pacientes VIH positivos y negativos, así como entre pacientes VIH inmunocomprometidos y no inmunocomprometidos. Conclusión: No encontramos interacciones claras entre VIH y NCC. Este resultado puede haber sido influenciado por el pequeño número de casos y la parcialidad de la información publicada. Un esfuerzo multiinstitucional, sistemático encaminado a reportar todos los casos de esta patología dual es necesario para confirmar estos resultados y esclarecer la relación entre patógenos.

Impact of bullying victimization on suicide and negative health behaviors among adolescents in Latin America / Repercusión de la intimidación en el suicidio y los comportamientos negativos en materia de salud de la población adolescente en América Latina

ABSTRACT Objective To compare the prevalence of bullying victimization, suicidal ideation, suicidal attempts, and negative health behaviors (current tobacco use, recent heavy alcohol use, truancy, involvement in physical fighting, and unprotected sexual intercourse) in five different Latin American countries and determine the association of bullying victimization with these outcomes, exploring both bullying type and frequency. Methods Study data were from Global School–based Student Health Surveys from Bolivia, Costa Rica, Honduras, Peru, and Uruguay, which covered nationally representative samples of school-going adolescents. The surveys used a two-stage clustered sample design, sampling schools and then classrooms. Logistic regression models were run to determine the statistical significance of associations with bullying. Results Among the 14 560 school-going adolescents included in this study, the prevalence of any bullying victimization in the past 30 days was 37.8%. Bullying victimization was associated with greater odds of suicidal ideation with planning (adjusted odds ratio (AOR): 3.12; P < 0.0001) and at least one suicide attempt (AOR: 3.07; P < 0.0001). An increasing exposure–response effect of increasing days of bullying victimization on suicide outcomes was also observed. Bullying victimization was associated with higher odds of current tobacco use (AOR: 2.14; P < 0.0001); truancy (AOR: 1.76; P < 0.0001); physical fighting (AOR: 2.40; P < 0.0001); and unprotected sexual intercourse (AOR: 1.77; P < 0.0001). Conclusions Although the prevalence of bullying victimization varied by country, its association with suicidal ideation and behavior and negative health behaviors remained relatively consistent. Addressing bullying needs to be made a priority in Latin America, and an integrated approach that also includes mental and physical health promotion is needed.

RESUMEN Objetivo Comparar la prevalencia de la intimidación, la ideación suicida, el intento de suicidio y los comportamientos negativos en materia de salud (consumo actual de tabaco, consumo reciente de cantidades excesivas de alcohol, ausentismo escolar, participación en riñas y relaciones sexuales sin protección) en cinco países latinoamericanos, y determinar la asociación de la condición de víctima de intimidación con estos resultados, tomando en cuenta tanto el tipo de intimidación como la frecuencia. Métodos Los datos para el estudio fueron tomados de las Encuestas mundiales de salud de los estudiantes realizada en las escuelas (EMSEE) de Bolivia, Costa Rica, Honduras, Perú y Uruguay, que incluyeron muestras representativas de adolescentes que asistían a la escuela a nivel nacional. Las encuestas se realizaron con el diseño de conglomerados en dos etapas, por el que seleccionaron primero escuelas y luego aulas. Se aplicaron modelos de regresión logística para determinar la significación estadística de la asociación con la intimidación. Resultados Entre los 14 560 adolescentes que asistían a la escuela incluidos en este estudio, la prevalencia de víctimas de algún tipo de intimidación en los 30 últimos días fue de 37,8%. La condición de víctima de intimidación se asoció con mayor probabilidad de ideación suicida con planes concretos (razón de posibilidades ajustada: 3,12; P < 0,0001) y al menos un intento de suicidio (razón de posibilidades ajustada: 3,07; P < 0,0001). En los resultados relacionados con el suicidio también se observó un efecto del aumento de la exposición (más días de intimidación) en la respuesta. La condición de víctima de intimidación se asoció con mayor probabilidad de consumo actual de tabaco (razón de posibilidades ajustada: 2,14; P < 0,0001); ausentismo escolar (razón de posibilidades ajustada 1,76; P < 0,0001); participación en riñas (razón de posibilidades ajustada 2,40 P < 0,0001), y relaciones sexuales sin protección (razón de posibilidades ajustada: 1,77; P < 0,0001). Conclusiones Si bien la prevalencia de la intimidación varió de un país a otro, su asociación con la ideación y el comportamiento suicidas y comportamientos negativos en materia de salud permaneció relativamente constante. Abordar la intimidación debe ser una prioridad en América Latina y se necesita un enfoque integrado que también incluya la promoción de la salud mental y física.

Differences in nutritional status, physical activity, and fruit and vegetable consumption in urban and rural school-going adolescents in paute, ecuador

Ecuador is undergoing a nutrition transition where overweight/obesity coexist with undernutrition. The objective of this study was to determine nutritional status, physical activity, fruit and vegetables consumption frequency among school-going adolescents in the canton of Paute and further explore if these variables were differential by urban vs. rural residence. We conducted a cross-sectional study using a random sample of students aged 12 to 19 years from the only two public secondary schools in the canton Paute. We determined nutritional status according to the World Health Organization criteria. Demographics, physical activity habits, fruit and vegetable consumption frequency were determined by questionnaires. Of the total of 314 students, 44.9% lived in urban area and 55.1% in rural area. The prevalence of overweight/obesity was significantly higher among students with urban vs. rural residence (28.4% vs. 17.9%; P=.03). The prevalence of stunting was significantly higher among students with rural vs. urban residence (31.8% vs. 16.3%; P=.002). There were no significant differences detected between groups in the frequency of consumption of fruits and vegetables. Urban residence was associated with a greater mean number of minutes of outdoor recreation after school (76.0 minutes vs. 57.1 minutes; P=.02), greater weekly hours of planned physical activity (2.0 hours vs. 1.6 hours; P=.007), and greater daily screen time in front of a television or computer (3.2 hours vs. 2.5 hours; P<.001). Interventions to prevent or reduce overweight/obesity in Paute and other similar areas with students from both urban and rural areas should consider place of residence in their design(AU)

Ecuador experimenta una transición nutricional donde el sobrepeso y la obesidad coexisten con la desnutrición. El objetivo de este estudio fue determinar estado nutricional, actividad física, consumo de frutas y verduras en adolescentes del cantón Paute-Ecuador y explorar las diferencias entre residencia urbana y rural. Se realizó un estudio transversal, con una muestra aleatoria de estudiantes de 12 a 19 años de edad en los dos únicos colegios de Paute. Se determinó el estado nutricional con el criterio de Organización Mundial de la Salud. Se determinó lugar de residencia, actividad física y frecuencia de consumo de frutas y verduras mediante cuestionarios. De los 314 estudiantes, 44,9% vivían en área urbana y 55,1% en área rural. La prevalencia de sobrepeso/obesidad fue más alta entre estudiantes del área urbana vs los del área rural (28,4% vs 17,9%; p=0,03). La prevalencia de talla baja fue mayor en área rural comparado con área urbana (31,8% vs 16,3%; p=0,002). No se encontraron diferencias significativas en el consumo de frutas y verduras. Los estudiantes del área urbana tuvieron un mayor promedio de minutos de actividad física después del colegio (76,0 vs 57,1 minutos; p=0,02), mayor número de horas de actividad física a la semana (2,0 vs 1,6 horas; p=0,007), y mayor tiempo frente a la pantalla del televisor o computador (3,2 vs 2,5 horas; p<0,001). Las intervenciones para prevenir o reducir el sobrepeso/obesidad en Paute y otras áreas similares con estudiantes de áreas urbana y rural deben considerar el lugar de residencia en sus diseños(AU)

The relationship between neurocysticercosis and epilepsy: an endless debate / A relação entre neurocisticercose e epilepsia: um debate interminável

Neurocysticercosis (NC), or cerebral infection with Taenia solium, is an important public health problem worldwide. Among the neurological sequelae of NC, seizures have been described as the most common symptom. Acute symptomatic seizures often result from degeneration of a viable cyst; however, not all of these patients with acute or provoked seizures will develop epilepsy (i.e., recurrent unprovoked seizures). Because of the high prevalence of epilepsy and NC, a causal, as well as incidental relationship between the two may exist. The epileptogenicity of calcified cysts as well as the potential association between NC and hippocampal sclerosis necessitates future research. Antihelminthic treatment of NC results in disappearance of viable cysts in about one-third of patients with parenchymal disease, but a reduction in seizure recurrence has not been demonstrated in randomized controlled trials. Prevention is critical to reduce the burden of seizure and epilepsy related to NC.

A neurocisticercose (NC) ou infecção cerebral pela Taenia solium é importante problema de saúde pública em todo o mundo. Entre as sequelas neurológicas da NC, as crises convulsivas têm sido descritas como os sintomas mais frequentes. Crises convulsivas sintomáticas agudas resultam, muitas vezes, da degeneração de cistos viáveis; entretanto, nem todos os pacientes com NC e crises agudas ou provocadas desenvolvem epilepsia (i.e., crises recorrentes não provocadas). Pode haver uma relação entre epilepsia e NC, causal ou incidental, devido à alta prevalência de ambas. O potencial epileptogênico dos cistos calcificados assim como a possível associação entre NC e esclerose hipocampal ainda necessitam de futuras pesquisas. O tratamento anti-helmíntico da NC resulta no desaparecimento de cistos viáveis em cerca de 1/3 dos pacientes com a doença parenquimatosa, mas não foi demonstrada redução nas taxas de recorrência das crises convulsivas em estudos randomizados controlados. A prevenção é crítica para reduzir o contingente de crises convulsivas e epilepsia relacionadas à NC.

Applying a social-ecological lens to opinions about HIV self-testing among Kenyan truckers who declined to test: a qualitative study

HIV prevalence among truckers in Africa is high and testing rates suboptimal. With numerous African countries having approved HIV self-testing kits, more information on how to design acceptable and accessible self-testing programs for high-risk populations is necessary. We explored views about self-testing via in-depth interviews with 24 truckers participating in a randomised controlled trial who refused HIV testing. A social-ecological lens was used to guide data analysis and frame study findings. While most participants said that they would use an HIV self-test, perceived barriers and facilitators were identified at multiple levels. Many participants noted lack of time to test or obtain a self-test kit as a major barrier (intrapersonal) and varied in their views about self-testing with a partner (interpersonal). Participants offered programmatic/policy recommendations, suggesting that they preferred accessing self-test kits in settings where training could be provided. Participants believed they should be able to pick up multiple test kits at the same time and that the test kits should be free or low cost. These study findings will help guide the design of self-testing programs for truckers and other mobile populations